Fast and accurate read alignment for resequencing
نویسندگان
چکیده
منابع مشابه
Fast and accurate read alignment for resequencing
MOTIVATION Next-generation sequence analysis has become an important task both in laboratory and clinical settings. A key stage in the majority sequence analysis workflows, such as resequencing, is the alignment of genomic reads to a reference genome. The accurate alignment of reads with large indels is a computationally challenging task for researchers. RESULTS We introduce SeqAlto as a new ...
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Correspondence: [email protected] Center for Bioinformatics, Saarland University, Campus E2.1, 66123, Saarbrücken, Germany Max Planck Institute for Informatics, Saarbrücken, Germany Full list of author information is available at the end of the article †Equal contributor Abstract Read-based phasing allows to reconstruct the haplotype structure of a sample purely from sequencing reads. ...
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UNLABELLED Accurately mapping RNA-Seq reads to the reference genome is a critical step for performing downstream analysis such as transcript assembly, isoform detection and quantification. Many tools have been developed; however, given the huge size of the next generation sequencing datasets and the complexity of the transcriptome, RNA-Seq read mapping remains a challenge with the ever-increasi...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2012
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/bts450